Yes, a Computer Use Agent（CUA） can work across multiple monitors reliably as long as it has access to the complete display topology and coordinates. Modern CUAs read system-level monitor metadata—resolution, scaling, positions, and orientation—which lets them stitch all screens into a single coordinate space. Once the CUA knows where each monitor sits logically (left, right, above, etc.), it can interpret screenshots or event locations accurately. This prevents issues like clicking on the wrong monitor or misaligning cursor movements.
The main reliability challenge comes from inconsistent scaling, such as one monitor running at 100% DPI and another at 175%. A CUA must normalize coordinates by accounting for per-monitor scaling. Many systems provide APIs for this information, and CUAs translate physical pixels into consistent logical units before performing actions. When this pipeline works correctly, the CUA can drag windows between displays, interact with apps on any monitor, and respond to cursor movements without errors. For complex desktop environments, CUAs often refresh display metadata periodically to detect any changes.
Developers can optionally integrate multi-monitor state or application regions into a vector database such as Milvus or Zilliz Cloud. This is useful when different monitors are used for different applications—for example, dashboards, code editors, or administrative tools. By storing embeddings of past screen states, the CUA can recognize which monitor is displaying which application and adjust its search space accordingly. This enables faster and more accurate action planning across diverse multi-monitor setups.